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Etofenamate is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs relieve pain and reduce the inflammation and fever produced by the body's immune system. Etofenamate has been successfully used for a number a years to treat patients with acute or chronic rheumatic diseases. Rheumon Gel, one product used to treat pain and swelling, contains 5% w/w etofenamate.Etofenamate has analgesic, antirheumatic, antipyretic and anti-inflammatory properties. It is a non-selective COX inhibitor. It works by blocking an enzyme in the body known as cyclo-oxygenase (COX). Cyclo-oxygenase is involved in the production of numerous chemicals in the body, including those known as prostaglandins. Prostaglandins are produced by the body in response to the presence of injury or disease and they make the nerves more sensitive to pain impulses. Etofenamate inhibits prostaglandin synthesis, providing analgesic and anti-inflammatory relief.Etofenamate in gel form is effective in treating arthritis and soft tissue diseases of the musculoskeletal system. This includes muscular rheumatism, muscle pain, muscle stiffening (e.g. periarthritis of the shoulder), joint pain, lower back pain (lumbago), sciatica (ischialgia), and sports injuries, including tendonitis, contusions, and bursitis. Etofenamate's anti-pyretic qualities can help to initially cool the area of application.Etofenamate is also used to treat osteoarthritis, rheumatoid arthritis, and gout. Osteoarthritis occurs over time and is often due to the 'wear and tear' of joints, including the erosion of the cartilage that covers the end of bones. Rheumatoid arthritis occurs when the body's immune system mistakenly attacks the healthy tissue that lines the joints. The resulting damage to the joint causes inflammation and can be chronically debilitating. It commonly affects people in the 35 to 50 year age bracket but it can strike anyone at any time. Gout results from a combination of a genetic predisposition to the condition, obesity, and high levels of blood cholesterol and uric acid. It is caused by the formation of crystals of uric acid, usually in middle-aged men.Etofenamate in gel form is applied directly to inflamed tissue. Topical application means that it reaches affected tissue in therapeutically effective concentrations. Because it is applied directly to the affected area through a cutaneous surface, there are less systemic side effects. The exact bioavailability of etofenamate depends on a number of factors, including the cutaneous administration site and the level of skin moisture.Once Etofenamate is absorbed, it will increase plasma fenamate levels. It is then metabolised, with the etofenamate being excreted in the form of various metabolites and their conjugates. After being processed by the kidneys, most of it is excreted in the bile and the faeces.