Diphenhydramine Hydrochloride

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Mersyndol

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Panadol Night

Diphenhydramine hydrochloride (HCL) is a sedating antihistamine that is used to counter temporary sleep disturbance in adults. As an antihistamine, diphenhydramine hydrochloride blocks the effects of the compound histamine within the body. The chemical name for diphenhydramine hydrochloride is 2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride.

As well as being a sedative, diphenhydramine hydrochloride also has anticholinergic and antiemetic qualities. Anticholinergic means that it blocks the neurotransmitter acetylcholine and its antiemetic properties means that it alleviates nausea and vomiting, which is why it is also used to treat motion sickness.

Diphenhydramine hydrochloride is used in Panadol Night to help provide relief for those suffering from pain at night-time that is preventing them from getting to sleep. This can include rheumatic or muscle pain, neuralgia, backache, toothache, migraine, headache, and period pain.

Diphenhydramine hydrochloride is effective within 15 to 30 minutes of being taken orally. Its effects will last approximately 4 to 8 hours. Almost all of the diphenhydramine hydrochloride, about 95%, is metabolised by the liver.

Doxylamine Succinate

Doxylamine succinate is an ethanolamine derivative antihistamine that has a tendency to induce sedation. This is why it is used to help adults who experience occasional sleeplessness or insomnia. Its calmative properties help in the treatment of migraines and tension headaches, reducing the anxiety that can perpetuate pain.

Doxylamine succinate is an antihistamine that blocks the effectiveness of the substance histamine. It also has anticholinergic and antiemetic properties. Doxylamine succinate is used in Mersyndol to provide relief from tension headaches and migraines, as well as helping to relieve toothache, backache, and post-operative pain.

Doxylamine succinate taken orally is easily absorbed by the gastrointestinal tract. It has an eilmination half-life of about nine hours. Approximately 60% is excreted in the urine as unchanged doxylamine, as well as nordoxylamine and dinordoxylamine.

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